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She also had a recurring role on the short-lived CBS sitcom The Class as Fern Velch.
From 2007 to 2010, Gilbert has appeared in episodes of the CBS TV series The Big Bang Theory as Leslie Winkle, a scientist friend of Leonard Hofstadter played by Johnny Galecki, who had previously played Gilbert's love interest David Healy on Roseanne.
Gilbert won a Daytime Emmy in 2016 for Outstanding Entertainment Talk Show as producer and creator of the show.
Gilbert appeared in two films alongside Drew Barrymore, in Poison Ivy in 1992 and Riding In Cars With Boys in 2001.
Gilbert returned to prime time television in the fall of 2005 in the sitcom Twins on The WB network.
The sitcom was canceled after one season, when the WB and UPN networks merged as The CW and dropped a number of shows.
For many years, Gilbert remained private about her sexuality, choosing not to publicly discuss her personal life.
She falls in love with Joe Kelly who was investigating the murder.
Used by Heather during her stay at Forest Hill, Sarah eventually wised up to her after recovering and left town after telling her that she was onto her. He funds Sam Mc Call and Damian Spinelli's private eye agency.
Gilbert graduated from Yale University in 1997 with honors, majoring in Art with an emphasis on Photography.
Following appearances in television movies and a commercial for Kool-Aid, at 13 she landed the role of Darlene Conner, the sarcastic middle child, in Roseanne.